This summary describes enhancements made to IDA’s Defense Industrial Base Optimization Model (DIBOpt) to help with budget and procurement planning for chemical, biological, radiological, and nuclear (CBRN) medical countermeasures. The COVID-19 pandemic disrupted global supply chains, which, in turn, exacerbated previously existing challenges with procurement and inventory management of medical items for civilian and military uses. IDA successfully generated a set of products that were used to inform Program Objective Memorandum budget requests for acquiring CBRN medical countermeasures, purchasing plans to meet inventory requirements, and minimizing expirations where possible.