This handbook provides individuals who plan and execute NATO exercises with the resources to accomplish cross-disciplinary chemical, biological, radiological and nuclear (CBRN) defense and medical training, whether or not CBRN medical support is a primary focus of the exercise. For such training to be successful, a level of CBRN medical expertise is required for certain exercise planning tasks, but the individuals responsible for those tasks are often experts in areas other than CBRN medical support and lack ready access to CBRN medical expertise. To address this need, this handbook provides exercise planning materials created by CBRN medical subject matter experts to assist non-experts in exercise development.