Globalization is a phenomenon that is bringing the world closer together through the exchange of raw goods, products, services, information, knowledge, and culture. Unprecedented advancements in technology, communications, science, transport, and industry have quickened the pace of global integration. Due to the presence of a worldwide market, there is a wider range of options to choose from among the products and services for building information systems. To find the right balance between the benefits, costs, and risks associated with globalization, one needs to understand how globalization works, the issues and challenges, and the subsequent system design and policy choices. The growing trend of globalization demands a more inclusive and persistent approach for actively managing risks in building trusted information systems. This book chapter discusses several research areas that address the effects of globalization coupled with the increasing complexity of building trusted information systems.